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ASP 8477
CAS No. 906737-25-5
ASP 8477( ASP8477 | ASP-8477 )
Catalog No. M16516 CAS No. 906737-25-5
A novel potent, highly selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.99, 1.65 and 57.3 nM for human FAAH-1, FAAH-1 (P129T) and FAAH-2, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameASP 8477
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, highly selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.99, 1.65 and 57.3 nM for human FAAH-1, FAAH-1 (P129T) and FAAH-2, respectively.
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DescriptionA novel potent, highly selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.99, 1.65 and 57.3 nM for human FAAH-1, FAAH-1 (P129T) and FAAH-2, respectively; displays no appreciable binding affinity to or inhibition against a panel of 65 receptors, ion channels and transporters, including CB1, CB2 receptors and MAGL; elevates AEA concentrations in both plasma and brain in adolescent rats, significantly improves mechanical allodynia and thermal hyperalgesia in capsaicin-induced secondary hyperalgesia model (0.3-3mg/kg, p.o).Pain Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsASP8477 | ASP-8477
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PathwayMetabolic Enzyme/Protease
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TargetFAAH
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RecptorFAAH
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Research Area——
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Indication——
Chemical Information
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CAS Number906737-25-5
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Formula Weight325.368
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Molecular FormulaC18H19N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Watabiki T, et al. Eur J Pharmacol. 2017 Nov 15;815:42-48.
2. Bradford D, et al. Pain Med. 2017 Dec 1;18(12):2388-2400.
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