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SMBA1
CAS No. 906440-37-7
SMBA1( SMBA 1 | SMBA-1 | NSC 408730 )
Catalog No. M16513 CAS No. 906440-37-7
A potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 226 | In Stock |
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| 10MG | 332 | In Stock |
|
| 25MG | 540 | In Stock |
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| 50MG | 737 | In Stock |
|
| 100MG | 1014 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2037 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSMBA1
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation.
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DescriptionA potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation; shows no affinity for other Bcl2 family members, including Bcl2, Bcl-XL, Mcl-1, Bcl-w, Bfl-1/A1, Bid or Bak; facilitates Bax insertion into mitochondrial membranes and forming Bax oligomers, leads to cytochrome c release and apoptosis in human lung cancer cells; potently suppresses lung tumour growth via apoptosis by selectively activating Bax in vivo without significant normal tissue toxicity.
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In VitroWestern Blot Analysis Cell Line:A549 cells Concentration:0, 0.1, 1, 5, 10 μM Incubation Time:24 h Result:Increased the Bax expression in a dose-dependent manner
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In VivoAnimal Model:6-week-old male Nu/Nu mice (A549 lung cancer xenografts)Dosage:2, 10, 40, 60 mg/kg Administration:I.p.; once daily for 10 days Result:Supressed the tumor volume and increased levels of active caspase 3.
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SynonymsSMBA 1 | SMBA-1 | NSC 408730
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research Area——
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Indication——
Chemical Information
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CAS Number906440-37-7
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Formula Weight315.32
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Molecular FormulaC20H13NO3
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Purity>98% (HPLC)
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Solubility——
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SMILESOC1=CC=CC=C1/C=C2C3=C(C4=C\2C=CC=C4)C=CC([N+]([O-])=O)=C3
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Chemical Name(E)-2-((2-nitro-9H-fluoren-9-ylidene)methyl)phenol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xin M, et al. Nat Commun. 2014 Sep 17;5:4935.
2. Daniele S, et al. ACS Chem Neurosci. 2017 Apr 11. doi: 10.1021/acschemneuro.7b00023.
3. Li R, et al. Cancer Res. 2017 Jun 1;77(11):3001-3012.
4. Levesley J, et al. Neuro Oncol. 2017 Jul 20. doi: 10.1093/neuonc/nox134.
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