Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Calcium Channel - AMG1

AMG1

CAS No. 903591-53-7

AMG1( AMG 1 | AMG-1 )

Catalog No. M16497 CAS No. 903591-53-7

A novel specific CRAC channel inhibitor that blocks function of effector.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 873 Get Quote
50MG 1782 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    AMG1
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel specific CRAC channel inhibitor that blocks function of effector.
  • Description
    A novel specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo; potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM, strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively; shows potential for Th1/Th17-mediated autoimmune diseases.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AMG 1 | AMG-1
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    903591-53-7
  • Formula Weight
    413.732
  • Molecular Formula
    C18H9ClF5N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC(=C(C(=C1)F)C(=O)NC2=NC=C(N=C2)C3=C(C=CC(=C3)C(F)(F)F)Cl)F
  • Chemical Name
    N-(5-(2-chloro-5-(trifluoromethyl)phenyl)-2-pyrazinyl)-2,6-difluorobenzamid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kaufmann U, et al. J Immunol. 2016 Jan 15;196(2):573-85.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • MMK 1

    Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proinflammatory cytokines IL-1β and IL-6. Also activates the neutrophil superoxide-generating NADPH-oxidase.

  • Imagabalin

    Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2.

  • Levamlodipine

    Amlodipine is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.

Sign In Join Free