VU 0240551( VU0240551 )

Catalog No. M16441 CAS No. 893990-34-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

VU 0240551
Note

Research use only, not for human use.
Brief Description

VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells.
Description

VU 0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells; displays >100-fold selectivity over NKCCl; also shows significant inhibition (>50% at 50 μM) of several GPCRs and key ion channels (hERG and L-Type Ca2+ channels).
In Vitro

VU 0240551 reduces the P cell response to GABA in a concentration-dependent manner with 75 and 100 μM treatments causing a significant reduction in GABA-elicited hyperpolarization while 25 μM had no significant effect.
In Vivo

VU 0240551 (10 μM) significantly blocks the chloride influx in cells from Eu rats but did not affect cells from SL rats.
Synonyms

VU0240551
Pathway

Membrane Transporter/Ion Channel
Target

Chloride Channel
Recptor

Chloride Channel
Research Area

Other Indications
Indication

——

CAS Number

893990-34-6
Formula Weight

342.43
Molecular Formula

C16H14N4OS2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 50 mg/mL 146.01 mM; H2O : < 0.1 mg/mL
SMILES

O=C(NC1=NC(C)=CS1)CSC2=NN=C(C3=CC=CC=C3)C=C2
Chemical Name

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

1. Deisz RA, et al. Neuroscience. 2014 Sep 26;277:831-41. 2. Chevy Q, et al. J Neurosci. 2015 Dec 2;35(48):15772-86.

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