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Home - Products - Cytoskeleton/Cell Adhesion Molecules - HSP - TRC-051384

TRC-051384

CAS No. 867164-40-7

TRC-051384( TRC051384 )

Catalog No. M16303 CAS No. 867164-40-7

A potent heat shock protein 70 (HSP70) inducer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TRC-051384
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent heat shock protein 70 (HSP70) inducer.
  • Description
    A potent heat shock protein 70 (HSP70) inducer, involves HSF1 activation; significantly reduces stroke associated neuronal injury and disability in a rat model of transient ischemic stroke; delays thrombus formation without increased bleeding risk in mice.
  • In Vitro
    TRC051384, dose dependently induces HSP70B mRNA by several hundred folds in both HeLa and rat primary mixed neurons. Treatment with TRC051384 results in significant dose-dependent increase in HSF1 transcriptional activity and recovery of luciferase activity. TRC051384 results in 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM of LPS-induced TNF-α expression in differentiated THP-1 cell line.
  • In Vivo
    Treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. Significant improvement in survival (50% by day2 and 67.3% by day 7) is observed with TRC051384 treatment initiated at 4 hours after ischemia onset. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity.
  • Synonyms
    TRC051384
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP70
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    867164-40-7
  • Formula Weight
    465.54
  • Molecular Formula
    C25H31N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥100 mg/mL
  • SMILES
    O=C(NC1=CC=C(C(/C=C/C2=NC(N3CCOCC3)=CC=C2)=O)C=C1)NCCN4CCOCC4
  • Chemical Name
    Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mohanan A, et al. Neuropharmacology. 2011 May;60(6):991-9. 2. Allende M, et al. Cardiovasc Res. 2016 Jun 1;110(3):309-18.
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