TRC-051384

Research use only, not for human use.

A potent heat shock protein 70 (HSP70) inducer.

A potent heat shock protein 70 (HSP70) inducer, involves HSF1 activation; significantly reduces stroke associated neuronal injury and disability in a rat model of transient ischemic stroke; delays thrombus formation without increased bleeding risk in mice.

TRC051384, dose dependently induces HSP70B mRNA by several hundred folds in both HeLa and rat primary mixed neurons. Treatment with TRC051384 results in significant dose-dependent increase in HSF1 transcriptional activity and recovery of luciferase activity. TRC051384 results in 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM of LPS-induced TNF-α expression in differentiated THP-1 cell line.

Treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. Significant improvement in survival (50% by day2 and 67.3% by day 7) is observed with TRC051384 treatment initiated at 4 hours after ischemia onset. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity.

TRC051384

Cytoskeleton/Cell Adhesion Molecules

HSP

HSP70

Metabolic Disease

——

867164-40-7

465.54

C25H31N5O4

>98% (HPLC)

DMSO: ≥100 mg/mL

O=C(NC1=CC=C(C(/C=C/C2=NC(N3CCOCC3)=CC=C2)=O)C=C1)NCCN4CCOCC4

Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-

(-20℃)

With Ice Pack

≥ 2 years