MMAF-OMe( Monomethyl auristatin F methyl ester )

Catalog No. M16260 CAS No. 863971-12-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

MMAF-OMe
Note

Research use only, not for human use.
Brief Description

An antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.
Description

An antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells; an ADC payload.
In Vitro

2.5F-Fc and 2.5F-Fc-MMAF have similar IC50?values (6.9±1.1 vs. 8.3±1.3 nM, respectively), indicating that MMAF conjugation has negligible impact on integrin-binding affinity.
In Vivo

——
Synonyms

Monomethyl auristatin F methyl ester
Pathway

Antibody Drug Conjugates (ADC)
Target

ADC Cytotoxin
Recptor

ADC Cytotoxin
Research Area

Cancer
Indication

——

CAS Number

863971-12-4
Formula Weight

745.9887
Molecular Formula

C40H67N5O8
Purity

>98% (HPLC)
Solubility

DMSO
SMILES

CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(CC2=CC=CC=C2)C(=O)OC)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC
Chemical Name

L-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester