Cart
sales@molnova.com
MMAF-OMe
CAS No. 863971-12-4
MMAF-OMe( Monomethyl auristatin F methyl ester )
Catalog No. M16260 CAS No. 863971-12-4
An antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 32 | In Stock |
|
| 10MG | 49 | In Stock |
|
| 25MG | 78 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMMAF-OMe
-
NoteResearch use only, not for human use.
-
Brief DescriptionAn antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.
-
DescriptionAn antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells; an ADC payload.
-
In Vitro2.5F-Fc and 2.5F-Fc-MMAF have similar IC50?values (6.9±1.1 vs. 8.3±1.3 nM, respectively), indicating that MMAF conjugation has negligible impact on integrin-binding affinity.
-
In Vivo——
-
SynonymsMonomethyl auristatin F methyl ester
-
PathwayAntibody Drug Conjugates (ADC)
-
TargetADC Cytotoxin
-
RecptorADC Cytotoxin
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number863971-12-4
-
Formula Weight745.9887
-
Molecular FormulaC40H67N5O8
-
Purity>98% (HPLC)
-
SolubilityDMSO
-
SMILESCCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(CC2=CC=CC=C2)C(=O)OC)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC
-
Chemical NameL-Phenylalanine, N-methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-, methyl ester
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog
related products
-
(4-NH2)-Exatecan
(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).
-
Esperamicin A1
Esperamicin A1 is an enediyne antitumor antibiotics of bacterial origin; acts by binding to DNA and causes strand scission.
-
alpha-Amanitin
α-Amanitin, an 8-Aa cyclic peptide, is an selective inhibitor of RNA polymerase II and III; a suitable toxic ADC payload for antibody-drug conjugates design.
