PF-00446687 hydrochloride( PF-446687 | PF00446687 )

Catalog No. M16241 CAS No. 862282-10-8

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Product Name

PF-00446687 hydrochloride
Note

Research use only, not for human use.
Brief Description

PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
Description

PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM; displays >100-fold selectivity over MC1R/1 uM); is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.Sexual Dysfunction Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

PF-446687 | PF00446687
Pathway

GPCR/G Protein
Target

Melanocortin Receptor
Recptor

Melanocortin Receptor
Research Area

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Indication

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CAS Number

862282-10-8
Formula Weight

507.06
Molecular Formula

C28H37ClF2N2O2
Purity

>98% (HPLC)
Solubility

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SMILES

O=C([C@@H]1CN(C(C)(C)C)C[C@H]1C2=CC=C(F)C=C2F)N3C[C@@H](C)[C@@](C4=CC=CC=C4)(O)[C@@H](C)C3.[H]Cl
Chemical Name

(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-phenylpiperidin-4-ol hydrochloride

1. Lansdell MI, et al. J Med Chem. 2010 Apr 22;53(8):3183-97. 2. Modi ME, et al. Neuropsychopharmacology. 2015 Jul;40(8):1856-65.

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