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PF-00446687 hydrochloride
CAS No. 862282-10-8
PF-00446687 hydrochloride( PF-446687 | PF00446687 )
Catalog No. M16241 CAS No. 862282-10-8
PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1413 | Get Quote |
|
| 50MG | 2862 | Get Quote |
|
| 100MG | 3870 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePF-00446687 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionPF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
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DescriptionPF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM; displays >100-fold selectivity over MC1R/1 uM); is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.Sexual Dysfunction Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsPF-446687 | PF00446687
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PathwayGPCR/G Protein
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TargetMelanocortin Receptor
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RecptorMelanocortin Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number862282-10-8
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Formula Weight507.06
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Molecular FormulaC28H37ClF2N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C([C@@H]1CN(C(C)(C)C)C[C@H]1C2=CC=C(F)C=C2F)N3C[C@@H](C)[C@@](C4=CC=CC=C4)(O)[C@@H](C)C3.[H]Cl
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Chemical Name(3R,4R,5S)-1-{[(3S,4R)-1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]carbonyl}-3,5-dimethyl-4-phenylpiperidin-4-ol hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lansdell MI, et al. J Med Chem. 2010 Apr 22;53(8):3183-97.
2. Modi ME, et al. Neuropsychopharmacology. 2015 Jul;40(8):1856-65.
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