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Retaspimycin hydrochloride
CAS No. 857402-63-2
Retaspimycin hydrochloride( IPI-504 | IPI504 | IPI 504 )
Catalog No. M16221 CAS No. 857402-63-2
A water-soluble derivative of 17-AAG and HSP90 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 672 | In Stock |
|
| 100MG | 1125 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRetaspimycin hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA water-soluble derivative of 17-AAG and HSP90 inhibitor.
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DescriptionA water-soluble derivative of 17-AAG and HSP90 inhibitor; induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors.Lung Cancer Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsIPI-504 | IPI504 | IPI 504
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number857402-63-2
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Formula Weight624.1652
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Molecular FormulaC31H46ClN3O8
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 56 mg/mL
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SMILESCC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=C(C(=C2O)C1)NCC=C)O)C)OC)OC(=O)N)C)C)O)OC.Cl
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Chemical NameGeldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Floris G, et al. Mol Cancer Ther. 2011 Oct;10(10):1897-908.
2. Hanson BE, et al. Expert Opin Investig Drugs. 2009 Sep;18(9):1375-83.
3. Oh WK, et al. Urology. 2011 Sep;78(3):626-30.
4. Siegel D, et al. Leuk Lymphoma. 2011 Dec;52(12):2308-15.
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