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Roxadustat
CAS No. 808118-40-3
Roxadustat( FG4592 | FG-4592 )
Catalog No. M16021 CAS No. 808118-40-3
Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 43 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 64 | In Stock |
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| 50MG | 82 | In Stock |
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| 100MG | 110 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 267 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRoxadustat
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NoteResearch use only, not for human use.
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Brief DescriptionRoxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM.
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DescriptionRoxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM; FG-4592 stimulates erythropoiesis, regulates iron metabolism, and reduces hepcidin, demonstrates potential for treatment of anemia.Anemia Phase 3 Clinical(In Vitro):Roxadustat (5-50 μM; 6 hours) significantly inhibits TBHP-induced apoptosis in PC12 cells.Roxadustat (50 μM; 6 hours) stabilizes HIF-1α protein expression in PC12 cells.(In Vivo):Roxadustat (50 mg/kg; i.p.; daily for 7 days) protects the survival of motor neurons and improves recovery from spinal cord injury.
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In VitroRoxadustat (5-50 μM; 6 hours) significantly inhibits TBHP-induced apoptosis in PC12 cells.Roxadustat (50 μM; 6 hours) stabilizes HIF-1α protein expression in PC12 cells.Apoptosis Analysis Cell Line:PC12 cells Concentration:5, 20, 50 μM Incubation Time:6 hours Result:Significantly inhibited TBHP-induced apoptosis.Western Blot Analysis Cell Line:PC12 cells Concentration:50 μM Incubation Time:6 hours Result:stabilized HIF-1α protein expression.
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In VivoRoxadustat (50 mg/kg; i.p.; daily for 7 days) protects the survival of motor neurons and improves recovery from spinal cord injury. Animal Model:12-week female C57BL/6 mice Dosage:50 mg/kg Administration: Intraperitoneal injection; daily for 7 days Result:Protected the survival of motor neurons and improved recovery from spinal cord injury.
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SynonymsFG4592 | FG-4592
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF-PH
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Research AreaOther Indications
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IndicationAnemia
Chemical Information
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CAS Number808118-40-3
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Formula Weight352.3407
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Molecular FormulaC19H16N2O5
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 46 mg/mL
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SMILESO=C(O)CNC(C1=C(O)C2=C(C(C)=N1)C=C(OC3=CC=CC=C3)C=C2)=O
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Chemical NameGlycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Besarab A, et al. J Am Soc Nephrol. 2016 Apr;27(4):1225-33.
2. Wu Y, et al. J Med Chem. 2018 Jun 28;61(12):5332-5349.
3. Provenzano R, et al. Clin J Am Soc Nephrol. 2016 Jun 6;11(6):982-91.
4. Jain IH, et al. Science. 2016 Apr 1;352(6281):54-61.
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