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Sulphadione
CAS No. 80-08-0
Sulphadione( 4,4'-Diaminodiphenyl sulfone | NSC 6091 )
Catalog No. M15997 CAS No. 80-08-0
Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | 29 | In Stock |
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Biological Information
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Product NameSulphadione
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NoteResearch use only, not for human use.
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Brief DescriptionDapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.
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DescriptionDapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.(In Vitro):Dapsone are added to cell lysates (100 μg of protein) and DHPS activity assay is tested. Dapsone exhibits an IC50 of 3.0 μg/ml for E. coli C600 in DHPS activity assay, but the growth of E. coli C600 is not inhibited at 256 μg/ml Dapsone. For the recombinant strain carrying M. leprae folP1 (pML101), Dapsone shows an IC50 of 0.06 μg/ml and a MIC of 1 μg/ml.(In Vivo):In L. major-infected BALB/c MiceDapsone (topical treatment; 50 mg/kg; twice daily; 30 days) leads to sizes lesions around 186 mm2 compared to 125 mm2 for control mice. Furthermore, the amount of DAP quantified in the lesions treated with DAP cream is 9.6±8.5 μg of DAP/mg of skin. However, the number of parasites found in the spleen is significantly lower in mice treated with the cream than in non-treated mice.
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In VitroDapsone are added to cell lysates (100 μg of protein) and DHPS activity assay is tested. Dapsone exhibits an IC50 of 3.0 μg/ml for E. coli?C600 in DHPS activity assay, but the growth of E. coli C600 is not inhibited at 256 μg/ml Dapsone. For the recombinant strain carrying?M. leprae folP1?(pML101), Dapsone shows an IC50?of 0.06 μg/ml and a MIC of 1 μg/ml.
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In VivoIn L. major-infected BALB/c Mice Dapsone (topical treatment; 50 mg/kg; twice daily; 30 days) leads to sizes lesions around 186 mm2?compared to 125 mm2?for control mice. Furthermore, the amount of DAP quantified in the lesions treated with DAP cream is 9.6±8.5 μg of DAP/mg of skin. However, the number of parasites found in the spleen is significantly lower in mice treated with the cream than in non-treated mice.
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Synonyms4,4'-Diaminodiphenyl sulfone | NSC 6091
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number80-08-0
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Formula Weight248.3
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Molecular FormulaC12H12N2O2S
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Purity>98% (HPLC)
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SolubilityWater: 380 mg/L (at 37 °C)
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SMILESC1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
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Chemical Name4-(4-aminophenyl)sulfonylaniline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gengenbacher M, et al. FEMS Microbiol Lett. 2008 Oct;287(1):128-35.
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