AS-8351

Research use only, not for human use.

AS-8351 (NSC 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.

AS-8351 (NSC 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409; competes with α-ketoglutarate (α-KG) for chelating iron/Fe(II) in certain epi-genetic enzymes, such as the JmjC-domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.(In Vitro):AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.

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AS8351 | NSC 51355

Chromatin/Epigenetic

Histone Demethylase

Demethylase

Other Indications

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796-42-9

291.31

C17H13N3O2

>98% (HPLC)

DMSO: 29.1 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

OC1=CC=C2C=CC=CC2=C1/C=N/NC(C3=CC=NC=C3)=O

2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone

(-20℃)

With Ice Pack

≥ 2 years