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Oglemilast
CAS No. 778576-62-8
Oglemilast( GRC 3886 )
Catalog No. M15938 CAS No. 778576-62-8
Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 133 | Get Quote |
|
| 10MG | 228 | Get Quote |
|
| 25MG | 348 | Get Quote |
|
| 50MG | 446 | Get Quote |
|
| 100MG | 651 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameOglemilast
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NoteResearch use only, not for human use.
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Brief DescriptionOglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.
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DescriptionOglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.Asthma Phase 1 Discontinued.
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In VitroOglemilast (GRC 3886) has EC50s of 11.4 nM, 4.4 nM for PDE 4B1 and PDE 4D3 reporter cell lines, respectively.
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In Vivo——
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SynonymsGRC 3886
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research AreaInflammation/Immunology
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IndicationAsthma
Chemical Information
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CAS Number778576-62-8
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Formula Weight516.297
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Molecular FormulaC20H13Cl2F2N3O5S
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Purity>98% (HPLC)
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SolubilityDMSO : 4 mg/mL7.75 mM;H2O : < 0.1 mg/mL
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SMILESO=C(C1=C2C(OC3=CC=C(NS(=O)(C)=O)C=C23)=C(OC(F)F)C=C1)NC4=C(Cl)C=NC=C4Cl
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Chemical NameN-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Giembycz MA. Br J Pharmacol. 2008 Oct;155(3):288-90.
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