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OSU-03012
CAS No. 742112-33-0
OSU-03012( AR-12 | AR 12 | OSU 03012 )
Catalog No. M15834 CAS No. 742112-33-0
OSU-03012 (AR-12) is a novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 5 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 45 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 45 | In Stock |
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| 10MG | 75 | In Stock |
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| 25MG | 139 | In Stock |
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| 50MG | 258 | In Stock |
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| 100MG | 341 | In Stock |
|
| 200MG | 444 | In Stock |
|
| 500MG | 727 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOSU-03012
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NoteResearch use only, not for human use.
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Brief DescriptionOSU-03012 (AR-12) is a novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 5 uM.
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DescriptionOSU-03012 (AR-12) is a novel potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) with IC50 of 5 uM; induces apoptosis in PC-3 cells at low microM range, causes Akt dephosphorylation and inhibition of p70 S6 kinase activity; displays cytotocixity against a panel of 60 cell lines with mean GI50 of 3 uM; decreases incidences of carcinoma and metastasis in transgenic mouse model of prostate cancer.Blood Cancer Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsAR-12 | AR 12 | OSU 03012
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PathwayPI3K/Akt/mTOR signaling
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TargetPDK
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RecptorPDK1
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number742112-33-0
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Formula Weight460.45
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Molecular FormulaC26H19F3N4O
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Purity>98% (HPLC)
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SolubilityDMSO: 9 mg/mL (19.5 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESNCC(=O)NC1=CC=C(C=C1)N1N=C(C=C1C1=CC2=C(C=C1)C1=CC=CC=C1C=C2)C(F)(F)F
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Chemical Name2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Johnson AJ, et al. Blood. 2005 Mar 15;105(6):2504-9.
2. Tseng PH, et al. Blood. 2005 May 15;105(10):4021-7.
3. Zhu J, et al. Cancer Res. 2004 Jun 15;64(12):4309-18.
4. Baryawno N, et al. Cancer Res. 2010 Jan 1;70(1):266-76.
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