Calindol hydrochloride

Research use only, not for human use.

Calindol hydrochloride is a calcimimetic acting agent and positive allosteric modulator (agonist) of CaSR with EC50 of 0.31 uM.

Calindol hydrochloride is a calcimimetic acting agent and positive allosteric modulator (agonist) of CaSR with EC50 of 0.31 uM (stimulated 3H IP accumulation in CHO cells at 2 mM Ca2+); activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+); produces concentration-dependent hyperpolarizations of vascular myocytes from rat isolated mesenteric and porcine coronary arteries.

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GPCR/G Protein

CaSR

CaSR

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729610-18-8

336.863

C21H21ClN2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (296.86 mM)

CC(C1=CC=CC2=CC=CC=C21)NCC3=CC4=CC=CC=C4N3.Cl

N-[(1R)-1-(1-naphthalenyl)ethyl]-1H-indole-2-methanamine, monohydrochloride

(-20℃)

With Ice Pack

≥ 2 years