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Tecalcet
CAS No. 148717-54-8
Tecalcet( R-568 | NPS R-568 | KRN-568 | NPS-568 )
Catalog No. M12052 CAS No. 148717-54-8
Tecalcet (R-568;NPS R-568;KRN-568;NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTecalcet
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NoteResearch use only, not for human use.
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Brief DescriptionTecalcet (R-568;NPS R-568;KRN-568;NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.
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DescriptionTecalcet (R-568;NPS R-568;KRN-568;NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR; potentiates the effects of extracellular Ca2+ on [Ca2+]i and PTH secretion (IC50=27 nM in bovine parathyroid cells) without effect in the absence of extracellular Ca2+, does not affect responses elicited by the homologous mGluRs. Hyperparathyroidism Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsR-568 | NPS R-568 | KRN-568 | NPS-568
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PathwayGPCR/G Protein
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TargetCaSR
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RecptorCaSR
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Research AreaEndocrinology
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IndicationHyperparathyroidism
Chemical Information
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CAS Number148717-54-8
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Formula Weight303.83
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Molecular FormulaC18H22ClNO
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C1=CC(=CC=C1)OC)NCCCC2=CC=CC=C2Cl
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Chemical Name2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wada MJ Clin Invest. 1997 Dec 15;100(12):2977-83., et al.
2. Nemeth EF, et al. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4040-5.
3. Wada M, et al. Kidney Int. 2000 Jan;57(1):50-8.
4. Hammerland LG, et al. Mol Pharmacol. 1998 Jun;53(6):1083-8.
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