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NSC-319726
CAS No. 71555-25-4
NSC-319726( NSC319726 )
Catalog No. M15734 CAS No. 71555-25-4
NSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 54 | In Stock |
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| 2MG | 30 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 81 | In Stock |
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| 25MG | 151 | In Stock |
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| 50MG | 268 | In Stock |
|
| 100MG | 456 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNSC-319726
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NoteResearch use only, not for human use.
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Brief DescriptionNSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator.
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DescriptionNSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator; restores WT structure and function to the p53(R175) mutant; kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.
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In Vitro——
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In Vivo——
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SynonymsNSC319726
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PathwayApoptosis
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TargetMDM2-p53
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Recptorp53(R175)
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number71555-25-4
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Formula Weight234.3207
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Molecular FormulaC11H14N4S
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Purity>98% (HPLC)
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SolubilityDMSO: 27.5 mg/mL
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SMILESC/C(=N\NC(=S)N1CCC1)/C2=CC=CC=N2
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Chemical Name1-Azetidinecarbothioic acid, 2-[1-(2-pyridinyl)ethylidene]hydrazide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yu X, et al. Cancer Cell. 2012 May 15;21(5):614-25.
2. Yu X, et al. Oncotarget. 2014 Oct 15;5(19):8879-92.
3. Yu X, et al. Mol Pharmacol. 2017 Jun;91(6):567-575.
4.?Shimada K, et al. Cell Chem Biol. 2018 May 17;25(5):585-594.e7.
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