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Home - Products - PI3K/Akt/mTOR signaling - PDK - BX-912

BX-912

CAS No. 702674-56-4

BX-912( BX912 | BX 912 )

Catalog No. M15695 CAS No. 702674-56-4

BX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 81 In Stock
2MG 65 In Stock
5MG 78 In Stock
10MG 140 In Stock
25MG 297 In Stock
50MG 485 In Stock
100MG 654 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    BX-912
  • Note
    Research use only, not for human use.
  • Brief Description
    BX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM.
  • Description
    BX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM; blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BX912 | BX 912
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PDK
  • Recptor
    CDK2/CyclinE|Chk1|PDK1|PKA|VEGFR2?(KDR)
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    702674-56-4
  • Formula Weight
    471.3536
  • Molecular Formula
    C20H23BrN8O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(N1CCCC1)NC2=CC=CC(NC3=NC=C(Br)C(NCCC4=CNC=N4)=N3)=C2
  • Chemical Name
    1-Pyrrolidinecarboxamide, N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Feldman RI, et al. J Biol Chem. 2005 May 20;280(20):19867-74. 2. Mashukova A, et al. Mol Biol Cell. 2012 May;23(9):1664-74. 3. Sturm EM, et al. Eur J Immunol. 2015 May;45(5):1548-59.
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