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BX-912
CAS No. 702674-56-4
BX-912( BX912 | BX 912 )
Catalog No. M15695 CAS No. 702674-56-4
BX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 81 | In Stock |
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| 2MG | 65 | In Stock |
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| 5MG | 78 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 297 | In Stock |
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| 50MG | 485 | In Stock |
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| 100MG | 654 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBX-912
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NoteResearch use only, not for human use.
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Brief DescriptionBX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM.
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DescriptionBX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM; blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis.
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In Vitro——
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In Vivo——
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SynonymsBX912 | BX 912
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PathwayPI3K/Akt/mTOR signaling
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TargetPDK
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RecptorCDK2/CyclinE|Chk1|PDK1|PKA|VEGFR2?(KDR)
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number702674-56-4
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Formula Weight471.3536
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Molecular FormulaC20H23BrN8O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N1CCCC1)NC2=CC=CC(NC3=NC=C(Br)C(NCCC4=CNC=N4)=N3)=C2
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Chemical Name1-Pyrrolidinecarboxamide, N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Feldman RI, et al. J Biol Chem. 2005 May 20;280(20):19867-74.
2. Mashukova A, et al. Mol Biol Cell. 2012 May;23(9):1664-74.
3. Sturm EM, et al. Eur J Immunol. 2015 May;45(5):1548-59.
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