Triclabendazole( Triclabendazole )

Catalog No. M15626 CAS No. 68786-66-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Triclabendazole
Note

Research use only, not for human use.
Brief Description

Triclabendazole is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.
Description

Triclabendazole is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.
In Vitro

Cell Cytotoxicity AssayCell Line:MCF-7 and MDA-MB-231 cells Concentration:20 μM, 40 μM, 80 μM, 160 μM, 320 μM,Incubation Time:24 h, 48 h Result:Significantly decreased the metabolic activity.Apoptosis Analysis Cell Line:MCF-7 and MDA-MB-231 cells Concentration:40 μM, 80 μM, 160 μM Incubation Time:24 h Result:Significantly induced apoptosis at 160 μM.Up-regulated the expression of Bax and down-regulated the expression of Bcl-2. Activated and cleaved caspase-8 and caspase-9 in a dose-dependent manner.
In Vivo

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Synonyms

Triclabendazole
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Microtubule/Tubulin
Recptor

Tubulin
Research Area

Infection
Indication

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CAS Number

68786-66-3
Formula Weight

359.66
Molecular Formula

C14H9CI3N2OS
Purity

>98% (HPLC)
Solubility

DMSO: 72 mg/mL (200.18 mM)
SMILES

CSC1=NC2=CC(OC3=CC=CC(Cl)=C3Cl)=C(Cl)C=C2N1
Chemical Name

6-Chloro-5-(2,3-dichlorophenoxy)-2-methylsulfanyl-1H-benzimidazole

1.Moll L, et al. Vet Parasitol, 2000 Jul 24, 91(1-2), 153-158.

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