Cart
sales@molnova.com
4-Hydroxytamoxifen
CAS No. 68392-35-8
4-Hydroxytamoxifen( Afimoxifene )
Catalog No. M15614 CAS No. 68392-35-8
A selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 49 | In Stock |
|
| 5MG | 45 | In Stock |
|
| 10MG | 68 | In Stock |
|
| 25MG | 123 | In Stock |
|
| 50MG | 198 | In Stock |
|
| 100MG | 305 | In Stock |
|
| 200MG | 458 | In Stock |
|
| 500MG | 734 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product Name4-Hydroxytamoxifen
-
NoteResearch use only, not for human use.
-
Brief DescriptionA selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.
-
DescriptionA selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen; exhibits more potent estrogen agonist/antagonist activity and can inhibit MCF-7 and MDA-MB-231 cell proliferation with IC50 values of 27 and 18 uM, respectively.Breast Cancer Phase 2 Clinical
-
In Vitro——
-
In Vivo——
-
SynonymsAfimoxifene
-
PathwayEndocrinology/Hormones
-
TargetEstrogen Receptor/ERR
-
RecptorOthers
-
Research AreaCancer
-
IndicationBreast Cancer
Chemical Information
-
CAS Number68392-35-8
-
Formula Weight387.5139
-
Molecular FormulaC26H29NO2
-
Purity>98% (HPLC)
-
SolubilityDMSO: 71 mg/mL (183.2 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
-
SMILESOC1=CC=C(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)/CC)C=C1
-
Chemical Name(Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Mansel R, et al. Breast Cancer Res Treat. 2007 Dec;106(3):389-97.
2. Desta Z, et al. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
3. Seeger H, et al. Horm Metab Res. 2004 May;36(5):277-80.
molnova catalog
related products
-
PHTPP
A potent, selective antagonist of estrogen ERβ receptor; exhibits 36-fold selective for ERβ, and is fully effective as an ERα antagonist.
-
Endoxifen (E-isomer)
Endoxifen E-isomer is the E-isomer of (Z)-Endoxifen. Endoxifen E-isomer has antiestrogenic effects.
-
Ginkgolic acid C17:1
Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes.
