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4-Hydroxytamoxifen
CAS No. 68392-35-8
4-Hydroxytamoxifen( Afimoxifene )
Catalog No. M15614 CAS No. 68392-35-8
A selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 49 | In Stock |
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| 5MG | 45 | In Stock |
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| 10MG | 68 | In Stock |
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| 25MG | 123 | In Stock |
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| 50MG | 198 | In Stock |
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| 100MG | 305 | In Stock |
|
| 200MG | 458 | In Stock |
|
| 500MG | 734 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name4-Hydroxytamoxifen
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NoteResearch use only, not for human use.
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Brief DescriptionA selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen.
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DescriptionA selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen; exhibits more potent estrogen agonist/antagonist activity and can inhibit MCF-7 and MDA-MB-231 cell proliferation with IC50 values of 27 and 18 uM, respectively.Breast Cancer Phase 2 Clinical
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In Vitro——
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In Vivo——
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SynonymsAfimoxifene
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorOthers
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number68392-35-8
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Formula Weight387.5139
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Molecular FormulaC26H29NO2
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Purity>98% (HPLC)
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SolubilityDMSO: 71 mg/mL (183.2 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESOC1=CC=C(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)/CC)C=C1
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Chemical Name(Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mansel R, et al. Breast Cancer Res Treat. 2007 Dec;106(3):389-97.
2. Desta Z, et al. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
3. Seeger H, et al. Horm Metab Res. 2004 May;36(5):277-80.
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