Choline chloride( —— )

Catalog No. M15578 CAS No. 67-48-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Choline chloride
Note

Research use only, not for human use.
Brief Description

Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate.
Description

Choline chloride is an organic compound and a quaternary ammonium salt, an acyl group acceptor and choline acetyltransferase substrate, also is an important additive in feed especially for chickens where it accelerates growth.
In Vitro

Cell Viability Assay Cell Line:Rat pheochromocytoma cells PC12 Concentration:0 or 70 μM Incubation Time:4 days Result:Showed the cell viability of 94% at 70 μM while cell viability of 83% at 0 μM.Reduced the number of cells with DNA breaks (characteristic of apoptosis) by 8.5% at 70 μM compared to the no treatment group.
In Vivo

Animal Model:Postoperative pain model of female C57/Bl6 miceDosage:0.2 and 100 mg/kg/h Administration:Subcutaneous injection, 24 or 48 hours Result:Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50 value of choline dose was 1.7 mg/kg/h.Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50 value of 4.7 mg/kg/h but not 24 hours.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

mAChR
Research Area

Other Indications
Indication

——

CAS Number

67-48-1
Formula Weight

139.63
Molecular Formula

C5H14ClNO
Purity

>98% (HPLC)
Solubility

Ethanol: 28 mg/mL (200.54 mM); Water: 28 mg/mL (200.54 mM); DMSO: 28 mg/mL (200.54 mM)
SMILES

[Cl-].C[N+](C)(C)CCO
Chemical Name

——

1.Lu XZ, et al. Br J Pharmacol. 2015 May 8

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