Cart
sales@molnova.com
BIO
CAS No. 667463-62-9
BIO( 6BIO | 6-BIO | GSK 3 IX | GSK 3 Inhibitor IX | MLS 2052 | MLS2052 )
Catalog No. M15548 CAS No. 667463-62-9
A cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 79 | In Stock |
|
| 2MG | 48 | In Stock |
|
| 5MG | 71 | In Stock |
|
| 10MG | 98 | In Stock |
|
| 25MG | 228 | In Stock |
|
| 50MG | 403 | In Stock |
|
| 100MG | 597 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1274 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBIO
-
NoteResearch use only, not for human use.
-
Brief DescriptionA cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM.
-
DescriptionA cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM; also inhibit CDK1/Cyclin B and CDK5/p25 (IC50, 320 nM and 83 nM); maintains the undifferentiated phenotype in HESCs and MESCs, sustains the expression of Oct-3/4, Rex-1 and Nanog; promotes proliferation in mammalian cardiomyocytes.
-
In Vitro——
-
In Vivo——
-
Synonyms6BIO | 6-BIO | GSK 3 IX | GSK 3 Inhibitor IX | MLS 2052 | MLS2052
-
PathwayPI3K/Akt/mTOR signaling
-
TargetGSK-3
-
RecptorCDK1/CyclinB|CDK2/CyclinA|CDK5/p35|GSK-3|Tyk2
-
Research AreaCardiovascular Disease
-
Indication——
Chemical Information
-
CAS Number667463-62-9
-
Formula Weight356.1735
-
Molecular FormulaC16H10BrN3O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 23 mg/mL
-
SMILESO=C(/C1=C2NC3=C(C\2=N/O)C=CC=C3)NC4=C1C=CC(Br)=C4
-
Chemical Name2H-Indol-2-one, 6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Meijer L, et al. Chem Biol. 2003 Dec;10(12):1255-66.
2. Tseng AS, et al. Chem Biol. 2006 Sep;13(9):957-63.
3. Sato N, et al. Nat Med. 2004 Jan;10(1):55-63.
molnova catalog
related products
-
CDK8-IN-12
CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent.
-
GSK-3β inhibitor 1
GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.GSK-3β inhibitor 1(compound 3a) inhibits GSK-3β with IC50 4.19 nM.?In a cell-based assay 3a shows no significant leucocyte toxicity at 10 M and is moderately cytotoxic against A549 cells.?
-
CHIR-99021 monohydro...
A potent, specific GSK-3 inhibitor with IC50 of 5 nM and 10 nM for GSK3β and GSK3α, respectively.
