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Calhex-231
CAS No. 652973-93-8
Calhex-231( Calhex231 )
Catalog No. M15482 CAS No. 652973-93-8
Calhex-231 is a potent negative allosteric modulator of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCalhex-231
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NoteResearch use only, not for human use.
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Brief DescriptionCalhex-231 is a potent negative allosteric modulator of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM.
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DescriptionCalhex-231 is a potent negative allosteric modulator of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM; inhibits myocyte hyperpolarization to the CaSR activator calindol and R-568.
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In Vitro——
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In Vivo——
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SynonymsCalhex231
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PathwayGPCR/G Protein
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TargetCaSR
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RecptorCaSR
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Research Area——
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Indication——
Chemical Information
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CAS Number652973-93-8
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Formula Weight406.954
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Molecular FormulaC25H27ClN2O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C1=CC=CC2=CC=CC=C21)NC3CCCCC3NC(=O)C4=CC=C(C=C4)Cl
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Chemical Name4-chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Petrel C, et al. J Biol Chem. 2003 Dec 5;278(49):49487-94.
2. Weston AH, et al. Circ Res. 2005 Aug 19;97(4):391-8.
3. Kessler A, et al. J Med Chem. 2006 Aug 24;49(17):5119-28.
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