Agipnon( Bemegride | Antibarbi | Agipnon | Ahypnon | Eukraton | Malysol | Mikedimide | Zentraleptin )

Catalog No. M15452 CAS No. 64-65-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Agipnon
Note

Research use only, not for human use.
Brief Description

Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.
Description

Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.(In Vitro):Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression.
In Vitro

Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression.
In Vivo

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Synonyms

Bemegride | Antibarbi | Agipnon | Ahypnon | Eukraton | Malysol | Mikedimide | Zentraleptin
Pathway

Membrane Transporter/Ion Channel
Target

GAT
Recptor

GABAR
Research Area

Neurological Disease
Indication

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1.Mistry DK, et al. Exp Physiol, 1990, 75(2),199-209.

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