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Piragliatin
CAS No. 625114-41-2
Piragliatin( RO 4389620 | R-1440 )
Catalog No. M15367 CAS No. 625114-41-2
Piragliatin (RO 4389620;R-1440) is an allosteric, potent Glucokinase (GK) activator with SC1.5 of 0.18 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePiragliatin
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NoteResearch use only, not for human use.
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Brief DescriptionPiragliatin (RO 4389620;R-1440) is an allosteric, potent Glucokinase (GK) activator with SC1.5 of 0.18 uM.
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DescriptionPiragliatin (RO 4389620;R-1440) is an allosteric, potent Glucokinase (GK) activator with SC1.5 of 0.18 uM; lowers pre- and postprandial glucose levels, improves the insulin secretory profile, increases β-cell sensitivity to glucose, and decreases hepatic glucose in vivo.Diabetes Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsRO 4389620 | R-1440
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetGlucokinase
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RecptorGlucokinase
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number625114-41-2
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Formula Weight421.896
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Molecular FormulaC19H20ClN3O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=NC=CN=C1)[C@@H](C2=CC=C(S(=O)(C)=O)C(Cl)=C2)C[C@@H]3CC(CC3)=O
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Chemical Name(2R)-2-(3-Chloro-4-(methylsulfonyl)phenyl)-3-((1R)-3-oxocyclopentyl)-N-pyrazinylpropanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sarabu R, et al. J Med Chem. 2012 Aug 23;55(16):7021-36.
2. Bonadonna RC, et al. J Clin Endocrinol Metab. 2010 Nov;95(11):5028-36.
3. Zhi J, et al. J Clin Pharmacol. 2016 Feb;56(2):231-8.
4. Kim MK, et al. PLoS One. 2013 Sep 19;8(9):e73340.
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