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TWS119
CAS No. 601514-19-6
TWS119( TWS 119 | TWS-119 )
Catalog No. M15239 CAS No. 601514-19-6
A GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; can induce neurogenesis in murine ESCs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 45 | In Stock |
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| 5MG | 41 | In Stock |
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| 10MG | 67 | In Stock |
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| 25MG | 130 | In Stock |
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| 50MG | 235 | In Stock |
|
| 100MG | 406 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTWS119
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NoteResearch use only, not for human use.
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Brief DescriptionA GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; can induce neurogenesis in murine ESCs.
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DescriptionA GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; can induce neurogenesis in murine ESCs; reduces Cdon levels and aberrant Cx43 activitiesin rat cardiomyocytes; attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats.
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In Vitro——
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In Vivo——
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SynonymsTWS 119 | TWS-119
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorGSK-3β
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number601514-19-6
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Formula Weight318.3293
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Molecular FormulaC18H14N4O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
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Chemical NamePhenol, 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ding S, et al. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7632-7.
2. Wang W, et al. Mol Neurobiol. 2016 Dec;53(10):7028-7036.
3. Jeong MH, et al. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1345-E1354.
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