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Rapamycin
CAS No. 53123-88-9
Rapamycin( Sirolimus )
Catalog No. M14886 CAS No. 53123-88-9
A macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 38 | In Stock |
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| 50MG | 45 | In Stock |
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| 100MG | 59 | In Stock |
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| 200MG | 100 | In Stock |
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| 500MG | 184 | In Stock |
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| 1G | 276 | In Stock |
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Biological Information
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Product NameRapamycin
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NoteResearch use only, not for human use.
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Brief DescriptionA macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM).
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DescriptionA macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM).Other Indication Approved(In Vitro):Rapamycin (GMP) (1 nM; 2-3 weeks) induces in vitro differentiation of human embryonic stem cell (hESCs) into mineralized osteoblasts.Rapamycin (GMP) (1 nM; 2-3 weeks) enhances the osteoblastic differentiation of human embryoid bodies (hEBs).Rapamycin (GMP) (20 nM; 4 h) serum-dependently promotes vascular smooth muscle cells (VSMCs) differentiation.Rapamycin (GMP) induces osteoblastic differentiation in rat osteoblast-like osteosarcoma cells.
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In VitroRapamycin (GMP) (1 nM; 2-3 weeks) induces in vitro differentiation of human embryonic stem cell (hESCs) into mineralized osteoblasts.Rapamycin (GMP) (1 nM; 2-3 weeks) enhances the osteoblastic differentiation of human embryoid bodies (hEBs).Rapamycin (GMP) (20 nM; 4 h) serum-dependently promotes vascular smooth muscle cells (VSMCs) differentiation.Rapamycin (GMP) induces osteoblastic differentiation in rat osteoblast-like osteosarcoma cells.
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In Vivo——
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SynonymsSirolimus
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptormTOR
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number53123-88-9
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Formula Weight914.1719
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Molecular FormulaC51H79NO13
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 28 mg/mL
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SMILESC[C@@H](C([C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(C[C@@H]([C@H](C)C[C@@H]1CC[C@@H](O)C(OC)C1)OC2=O)=O)=O)C[C@H](C)/C=C/C=C/C=C(C)/[C@@H](OC)C[C@H]3O[C@](C(C(N4[C@H]2CCCC4)=O)=O)(O)[C@H](C)CC3
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Chemical NameRapamycin
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Morris RE, et al. Transplant Proc. 1991 Feb;23(1 Pt 1):521-4.
2. Dumont FJ, et al. J Immunol. 1990 Jan 1;144(1):251-8.
3. Dumont FJ, et al. J Immunol. 1990 Feb 15;144(4):1418-24.
4. Edwards SR, et al. J Biol Chem. 2007 May 4;282(18):13395-401.
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