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Pifithrin-β hydrobromide
CAS No. 511296-88-1
Pifithrin-β hydrobromide( Cyclic Pifithrin-α hydrobromide | PFT-β hydrobromide )
Catalog No. M14763 CAS No. 511296-88-1
A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53; prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
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| 2MG | 32 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 81 | In Stock |
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| 25MG | 145 | In Stock |
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| 50MG | 207 | In Stock |
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| 100MG | 309 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePifithrin-β hydrobromide
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NoteResearch use only, not for human use.
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Brief DescriptionA cyclic analog of Pifithrin-α and a small molecule inhibitor of p53; prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM.
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DescriptionA cyclic analog of Pifithrin-α and a small molecule inhibitor of p53; prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM, sensitizes p53-deficient tumors to radiotherapy and chemotherapy and increases apoptosis in cancer cells.
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In VitroPifithrin-α hydrobromide (PFT β hydrobromide), an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects.
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In Vivo——
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SynonymsCyclic Pifithrin-α hydrobromide | PFT-β hydrobromide
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PathwayApoptosis
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TargetMDM2-p53
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Recptorp53
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number511296-88-1
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Formula Weight349.2886
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Molecular FormulaC16H17BrN2S
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Purity>98% (HPLC)
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SolubilityDMSO: 26 mg/mL
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SMILESCC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br
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Chemical NameImidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-, hydrobromide (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pietrancosta N, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1561-4.
2. Barchéchath SD, et al. J Med Chem. 2005 Oct 6;48(20):6409-22.
3. Zuco V, et al. Neoplasia. 2008 Jun;10(6):587-96.
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