AQ-101( AQ101 )

Catalog No. M11437 CAS No. 1353384-61-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

AQ-101
Note

Research use only, not for human use.
Brief Description

AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism.
Description

AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53; induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo; inhibits development of ALL in nude or SCID mice with a human ALL xenograft.
In Vitro

——
In Vivo

——
Synonyms

AQ101
Pathway

Apoptosis
Target

MDM2-p53
Recptor

MDM2-p53
Research Area

——
Indication

——

CAS Number

1353384-61-8
Formula Weight

331.708
Molecular Formula

C16H10ClNO5
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC(C=C1C2=O)=CC(O)=C1C(C3=C2C=CC=C3O)=O)CCl
Chemical Name

2-chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetamide

1. Gu L, et al. Mol Cancer Ther. 2018 Feb;17(2):497-507.

Calculator

molnova catalog