Ibudilast( AV 411 | KC-404 )

Catalog No. M14741 CAS No. 50847-11-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Ibudilast
Note

Research use only, not for human use.
Brief Description

Ibudilast(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor which has been marketed for treating asthma.
Description

Ibudilast(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor which has been marketed for treating asthma.
In Vitro

Western Blot Analysis Cell Line:Microglia Concentration:1~100 μM Incubation Time:24 hours Result:Suppressed both IL-1β and IL-6 production at 100 μM, and significantly suppresses TNF-α production at 10 and 100 μM. ?
In Vivo

——
Synonyms

AV 411 | KC-404
Pathway

Angiogenesis
Target

PDE
Recptor

PDE
Research Area

Inflammation/Immunology
Indication

——

CAS Number

50847-11-5
Formula Weight

230.51
Molecular Formula

C14H18N2O
Purity

>98% (HPLC)
Solubility

DMSO: 28 mg/mL; 100 mM in Ethanol
SMILES

CC(C)C(C1=C2C=CC=CN2N=C1C(C)C)=O
Chemical Name

2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one

1.Yamazaki T, et al. Eur J Pharmacol. 2010 Oct 29.

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