ITI214( ITI 214 | ITI-214 )

Catalog No. M12494 CAS No. 1642303-38-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ITI214
Note

Research use only, not for human use.
Brief Description

ITI-214 is a potent, selective, orally active phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM.
Description

ITI-214 is a potent, selective, orally active phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms; improves the memory processes of acquisition, consolidation, and retrieval across a broad dose range (0.1-10 mg/kg, po) without disrupting the antipsychotic-like activity of a clinical antipsychotic medication, shows potential for schizophrenia and Alzheimer's disease, movement disorders, attention deficit and hyperactivity disorders, and other central nervous system (CNS) and non-CNS disorders.Parkinson Disease Phase 2 Clinical.
In Vitro

——
In Vivo

Animal Model:Male Sprague-Dawley rats Dosage:0.1-10 mg/kg Administration:p.o.Result:Significantly enhanced memory performance in the test with a minimum effective dose of 3 mg/kg.
Synonyms

ITI 214 | ITI-214
Pathway

Angiogenesis
Target

PDE
Recptor

PDE
Research Area

Neurological Disease
Indication

Parkinson Disease

CAS Number

1642303-38-5
Formula Weight

605.5566
Molecular Formula

C29H29FN7O5P
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 30 mg/mL
SMILES

CN1C(=O)C2=C(N(N=C2N3C1=NC4C3CCC4)CC5=CC=C(C=C5)C6=NC(=CC=C6)F)NC7=CC=CC=C7.OP(=O)(O)O
Chemical Name

Cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, 2-[[4-(6-fluoro-2-pyridinyl)phenyl]methyl]-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-, (6aR,9aS)-, phosphate (1:1)

1. Li P, et al. J Med Chem. 2016 Feb 11;59(3):1149-64. 2. Snyder GL, et al. Psychopharmacology (Berl). 2016 Sep;233(17):3113-24.

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