Niclosamide

Research use only, not for human use.

Niclosamide(BAY2353) is used for the treatment of most tapeworm infections by inhibiting DNA replication.

Niclosamide(BAY2353) is used for the treatment of most tapeworm infections by inhibiting DNA replication.

Cell Viability Assay Cell Line:BD140A, SW-13 and NCI-H295R cells Concentration:0.6 nM-46 μM Incubation Time:Result:Inhibited cellular proliferation in adrenocortical carcinoma cell lines with the IC50 of 0.12 μM, 0.15 μM, and 0.53 μM in BD140A, SW-13, and NCI-H295R, respectively.Cell Viability Assay Cell Line:Hela cells Concentration:0.05-5 μM Incubation Time:24 hours Result:Inhibited STAT3-mediated luciferase reporter activity with an IC50 of 0.25 μM.Cell Viability Assay Cell Line:Vero E6 cells Concentration:10 μM Incubation Time:2 days Result:Inhibited the synthesis of viral antigens of SARS-CoV in Vero E6 cells.

Animal Model:Nu+/Nu+ mice injected with NCI-H295R cells Dosage:100 mg/kg, 200 mg/kg Administration:Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks Result:Showed a 60%-80% inhibition in tumor growth, as compared to the control group.

NSC 178296

JAK/STAT Signaling

STAT

STAT3

Infection

——

50-65-7

327.12

C13H8Cl2N2O4

>98% (HPLC)

Ethanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)

O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O

5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

(-20℃)

With Ice Pack

≥ 2 years