S3I-M2001( S3I M2001 | Bromohydroxyacetone phosphate )

Catalog No. M10032 CAS No. 1003580-86-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

S3I-M2001
Note

Research use only, not for human use.
Brief Description

S3I-M2001 (Bromohydroxyacetone phosphate) is an oxazole-based peptidomimetic of the STAT3 SH2 domain-binding phosphotyrosine peptide that selectively disrupts active STAT3:STAT3 dimers.
Description

S3I-M2001 (Bromohydroxyacetone phosphate) is an oxazole-based peptidomimetic of the STAT3 SH2 domain-binding phosphotyrosine peptide that selectively disrupts active STAT3:STAT3 dimers; inhibits Stat3-dependent transcriptional regulation of tumor survival genes, such as Bcl-xL; suppresses Stat3-dependent malignant transformation, survival, and migration and invasion of mouse and human cancer cells harboring persistently activated Stat3; inhibits growth of human breast tumor xenografts.
In Vitro

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In Vivo

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Synonyms

S3I M2001 | Bromohydroxyacetone phosphate
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

——
Indication

——

CAS Number

1003580-86-6
Formula Weight

508.511
Molecular Formula

C27H29N2O6P
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCCCCNC(=O)C1=C(OC(=N1)C2=CC=CC3=CC=CC=C32)CC4=CC=C(C=C4)OP(=O)(O)O
Chemical Name

4-{[4-(Hexylcarbamoyl)-2-(1-naphthyl)-1,3-oxazol-5-yl]methyl}phen yl dihydrogen phosphate

1. Siddiquee KA, et al. ACS Chem Biol. 2007 Dec 21;2(12):787-98.

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