Estradiol benzoate( β-Estradiol Benzoate | 17β-Estradiol 3-Benzoate | 17β-Oestradiol Benzoate | E2 Benzoate )

Catalog No. M14719 CAS No. 50-50-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Estradiol benzoate
Note

Research use only, not for human use.
Brief Description

Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.
Description

Estradiol benzoate is an estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.
In Vitro

Cell Cytotoxicity Assay Cell Line:HFFs Concentration:0-500 μM Incubation Time:72 h Result:Inhibited HFFs at the 50% toxicity of 34.11 μM.
In Vivo

Animal Model:Ovx miceDosage:20, 100 or 200 μg/kg Administration:Subcutaneous injection (s.c.)Result:Significantly reversed the lowered uterine weight induced by Ovx.Had no obvious effects on locomotor activity in Ovx mice.Effectively reversed the changes of enlarging the width of synaptic cleft and reducing the thickness of PSD induced by Ovx.Increased the number and density of synaptic vesicles by 4-week replacement with EB (100 μg/kg).
Synonyms

β-Estradiol Benzoate | 17β-Estradiol 3-Benzoate | 17β-Oestradiol Benzoate | E2 Benzoate
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

mERα| hERα
Research Area

Endocrinology
Indication

——

CAS Number

50-50-0
Formula Weight

376.49
Molecular Formula

C25H28O3
Purity

>98% (HPLC)
Solubility

DMSO: 75 mg/mL (199.2 mM)
SMILES

O=C(OC1=CC=C2[C@@]3([H])CC[C@]4(C)[C@@H](O)CC[C@@]4([H])[C@]3([H])CCC2=C1)C5=CC=CC=C5
Chemical Name

[(8R,9S,13S,14S,17S)-17-Hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] benzoate

1.Matthews J, et al. J Steroid Biochem Mol Biol, 2000, 74(4), 223-234.

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