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AEE-788
CAS No. 497839-62-0
AEE-788( AEE 788 | AEE788 | NVP-AEE 788 )
Catalog No. M14666 CAS No. 497839-62-0
A potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 35 | In Stock |
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| 5MG | 58 | In Stock |
|
| 10MG | 95 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 50MG | 309 | In Stock |
|
| 100MG | 464 | In Stock |
|
| 500MG | 1044 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAEE-788
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively.
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DescriptionA potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively; inhibits growth factor-induced EGFR and ErbB2 phosphorylation in cells with IC50 of 11 and 220 nM, respectively, demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines; shows antitumor and antiangiogenic activity in vivo.Brain Cancer Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsAEE 788 | AEE788 | NVP-AEE 788
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PathwayAngiogenesis
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TargetEGFR
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Recptorc-Abl|c-Fms|EGFR|FLT1|HER2/ErbB2
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Research AreaCancer
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IndicationBrain Cancer
Chemical Information
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CAS Number497839-62-0
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Formula Weight440.5832
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Molecular FormulaC27H32N6
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESC[C@@H](NC1=C2C(NC(C3=CC=C(CN4CCN(CC)CC4)C=C3)=C2)=NC=N1)C5=CC=CC=C5
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Chemical Name7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-[4-[(4-ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Traxler P, et al. Cancer Res. 2004 Jul 15;64(14):4931-41.
2. Goudar RK, et al. Mol Cancer Ther. 2005 Jan;4(1):101-12.
3. Park YW, et al. Clin Cancer Res. 2005 Mar 1;11(5):1963-73.
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