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Olmutinib (b)
CAS No. 1353550-13-6
Olmutinib (b)( HM-61713 | BI-1482694 )
Catalog No. M11438 CAS No. 1353550-13-6
Olmutinib (HM61713, BI-1482694) is a pontent and T790M-specific third-generation EGFR inhibitor for treatment of NSCLC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 51 | In Stock |
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| 2MG | 31 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 132 | In Stock |
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| 50MG | 176 | In Stock |
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| 100MG | 276 | In Stock |
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| 200MG | 452 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOlmutinib (b)
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NoteResearch use only, not for human use.
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Brief DescriptionOlmutinib (HM61713, BI-1482694) is a pontent and T790M-specific third-generation EGFR inhibitor for treatment of NSCLC.
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DescriptionOlmutinib (HM61713, BI-1482694) is a pontent and T790M-specific third-generation EGFR inhibitor for treatment of NSCLC.Lung Cancer Phase 2 Clinical(In Vitro):Olmutinib potently inhibits EGFR in HCC827 cells expressing EGFRDEL19 (IC50=9.2 nM) and H1975 cells expressing EGFRL858R/T790M (IC50=10 nM). In contrast, the IC50 of olmutinib against cells expressing EGFRWT is 2225 nM.
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In VitroOlmutinib potently inhibits EGFR in HCC827 cells expressing EGFRDEL19 (IC50=9.2 nM) and H1975 cells expressing EGFRL858R/T790M (IC50=10 nM). In contrast, the IC50 of olmutinib against cells expressing EGFRWT is 2225 nM.
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In Vivo——
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SynonymsHM-61713 | BI-1482694
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR(cell:H1975)|EGFR(cell:HCC827)
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number1353550-13-6
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Formula Weight486.5887
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Molecular FormulaC26H26N6O2S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 44 mg/mL
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SMILESCN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)SC=C4
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Chemical Name2-Propenamide, N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Song HN, et al. J Thorac Oncol. 2016 Apr;11(4):e45-7.
2. Patel H, et al. Eur J Med Chem. 2017 May 11. pii: S0223-5234(17)30388-4.
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