Cart
sales@molnova.com
HR22C16
CAS No. 462630-41-7
HR22C16( Monastroline )
Catalog No. M14558 CAS No. 462630-41-7
A potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameHR22C16
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM.
-
DescriptionA potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM, does not interact with other microtubule motor proteins; inhibits cell survival in both Taxol-sensitive and -resistant ovarian cancer cells with at least 15-fold greater efficacy than monastrol.
-
In Vitro——
-
In Vivo——
-
SynonymsMonastroline
-
PathwayCytoskeleton/Cell Adhesion Molecules
-
TargetKinesin
-
RecptorKinesin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number462630-41-7
-
Formula Weight389.455
-
Molecular FormulaC23H23N3O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1CC2=C(C(C3=CC=CC(O)=C3)N14)NC5=C2C=CC=C5)N(CCCC)C4=O
-
Chemical Name2-butyl-5-(3-hydroxyphenyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hotha S, et al. Angew Chem Int Ed Engl. 2003 May 30;42(21):2379-82.
2. Marcus AI, et al. J Biol Chem. 2005 Mar 25;280(12):11569-77.
molnova catalog
related products
-
Mps1-IN-3
Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
-
Monastrol (b)
A potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
-
UMK57
UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds, and can improve chromosome separation conservation by disrupting the stability of kinetosomal microtubule (k-MT) attachment during mitosis.
