MRK-623( MRK623 )

Catalog No. M14556 CAS No. 461449-78-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

MRK-623
Note

Research use only, not for human use.
Brief Description

MRK-623 is a potent, α2/α3 subunit functionally selectiviie GABAA receptor agonist.
Description

MRK-623 is a potent, α2/α3 subunit functionally selectiviie GABAA receptor agonist.
In Vitro

MRK-623 shows efficacy at human GABAA receptor subtypes expressed in L(tk-) cells measured by whole cell patch-clamp electrophysiology.
In Vivo

MRK-623 (oral gavage; 0.3, 1, and 3 mg/kg; once) shows anxiolytic effects in the rat elevated plus maze assay. Animal Model:RatDosage:0.3, 1, and 3 mg/kg Administration:Oral gavage; 0.3, 1, and 3 mg/kg; once Result:Showed 78% BZ site occupancy at 3 mg/kg, with an ID50 of 0.8 mg/kg.
Synonyms

MRK623
Pathway

Membrane Transporter/Ion Channel
Target

GAT
Recptor

GAT
Research Area

——
Indication

——

CAS Number

461449-78-5
Formula Weight

348.381
Molecular Formula

C20H17FN4O
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

2-(3-(4-fluoro-3-pyridin-3-yl-phenyl)-imidazo(1,2-a)pyrimidin-7-yl)-propan-2-ol

1. Shinday NM, et al. Neuropsychopharmacology. 2013 May;38(6):1006-14.

Calculator

molnova catalog