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MRK-623
CAS No. 461449-78-5
MRK-623( MRK623 )
Catalog No. M14556 CAS No. 461449-78-5
MRK-623 is a potent, α2/α3 subunit functionally selectiviie GABAA receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMRK-623
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NoteResearch use only, not for human use.
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Brief DescriptionMRK-623 is a potent, α2/α3 subunit functionally selectiviie GABAA receptor agonist.
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DescriptionMRK-623 is a potent, α2/α3 subunit functionally selectiviie GABAA receptor agonist.
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In VitroMRK-623 shows efficacy at human GABAA receptor subtypes expressed in L(tk-) cells measured by whole cell patch-clamp electrophysiology.
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In VivoMRK-623 (oral gavage; 0.3, 1, and 3 mg/kg; once) shows anxiolytic effects in the rat elevated plus maze assay. Animal Model:RatDosage:0.3, 1, and 3 mg/kg Administration:Oral gavage; 0.3, 1, and 3 mg/kg; once Result:Showed 78% BZ site occupancy at 3 mg/kg, with an ID50 of 0.8 mg/kg.
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SynonymsMRK623
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PathwayMembrane Transporter/Ion Channel
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TargetGAT
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RecptorGAT
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Research Area——
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Indication——
Chemical Information
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CAS Number461449-78-5
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Formula Weight348.381
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Molecular FormulaC20H17FN4O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-(3-(4-fluoro-3-pyridin-3-yl-phenyl)-imidazo(1,2-a)pyrimidin-7-yl)-propan-2-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shinday NM, et al. Neuropsychopharmacology. 2013 May;38(6):1006-14.
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