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BMS-345541 free base
CAS No. 445430-58-0
BMS-345541 free base( BMS345541 (free base) )
Catalog No. M14526 CAS No. 445430-58-0
A potent and selective IKK-2 inhibitor with IC50 of 0.3 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 102 | In Stock |
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| 25MG | 205 | In Stock |
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| 50MG | 335 | In Stock |
|
| 100MG | 493 | In Stock |
|
| 200MG | 705 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBMS-345541 free base
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective IKK-2 inhibitor with IC50 of 0.3 uM.
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DescriptionA potent and selective IKK-2 inhibitor with IC50 of 0.3 uM; less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε; inhibits LPS-stimulated TNFα, IL-1β, IL-8, and IL-6 in THP-1 cells with IC50 of1-5 uM; has excellent pharmacokinetics in mice.
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In Vitro——
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In Vivo——
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SynonymsBMS345541 (free base)
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorIKK1|IKK2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number445430-58-0
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Formula Weight255.3183
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Molecular FormulaC14H17N5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCc1ccc2c(c1)n3c(cnc3c(n2)NCCN)C
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Chemical Name1,2-Ethanediamine, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Burke JR, et al. J Biol Chem. 2003 Jan 17;278(3):1450-6.
2. McIntyre KW, et al. Arthritis Rheum. 2003 Sep;48(9):2652-9.
3. López-Guerra M, et al. Clin Cancer Res. 2009 Apr 15;15(8):2767-76.
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