LDN 91946( LDN91946 )

Catalog No. M14496 CAS No. 439946-22-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LDN 91946
Note

Research use only, not for human use.
Brief Description

LDN 91946 is a selective, uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with Ki of 2.8 uM.
Description

LDN 91946 is a selective, uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with Ki of 2.8 uM, exhibits no activity against other cysteine hydrolase (UCH-L3, TGase 2, papain and caspase-3).
In Vitro

LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM. There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM.
In Vivo

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Synonyms

LDN91946
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

——
Indication

——

CAS Number

439946-22-2
Formula Weight

316.32
Molecular Formula

C17H12N6O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 83.33 mg/mL (265.11 mM)
SMILES

C1(NC2=CC=CN=C2)=NC=C(C3=NC=NC=C3)C(C4=CC=CO4)=N1
Chemical Name

3-amino-2-(benzoyl)-6-oxo-7H-thieno[3,2-e]pyridine-5-carboxylic acid

1. Mermerian AH, et al. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32. 2. Coulombe J, et al. Front Aging Neurosci. 2014 Jun 19;6:129.

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