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CX 4338
CAS No. 41609-06-7
CX 4338( CX4338 | CX-4338 )
Catalog No. M14425 CAS No. 41609-06-7
CX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCX 4338
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NoteResearch use only, not for human use.
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Brief DescriptionCX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM.
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DescriptionCX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM; shows little to no inhibition of CXCR4-mediated β-arrestin-2 recruitment at 100 uM; inhibits receptor internalization, while enhancing CXCR2-mediated MAPK activation; inhibits CXCL8-induced chemotaxis in CXCR2-overexpressing cells and human neutrophils; significantly reduces neutrophils in bronchoalveolar lavage induced by LPS in mice.
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In Vitro——
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In Vivo——
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SynonymsCX4338 | CX-4338
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number41609-06-7
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Formula Weight364.507
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Molecular FormulaC22H24N2OS
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1(CC(=C(C(=O)C1)C(=S)NC2=CC=CC=C2)NCC3=CC=CC=C3)C
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Chemical Name2-(benzylamino)-4,4-dimethyl-6-oxo-N-phenylcyclohex-1-enecarbothioamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ha H, et al. Br J Pharmacol. 2014 Mar;171(6):1551-65.
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