α-NETA

Research use only, not for human use.

A small molecule CMKLR1 antagonist that inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 (EC50=9.7 nM).

A small molecule CMKLR1 antagonist that inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 (EC50=9.7 nM); inhibits chemerin-triggered CMKLR1+ cell migration, suppresses CNS autoimmune inflammatory disease in vivo; also inhibits choline acetyltransferase with IC50 of 9 uM.

β-NETA exhibits no effects at muscarinic receptors, ganglionic nicotinic receptors, skeletal muscular nicotinic receptors, cholinesterases or carnitine acetyltransferase at concentrations which inhibits ChA. At concentrations higher than the IC50 value to inhibit ChA, β-NETA antagonizes the effect of acetylcholine (ED50=100 μM), histamine and KCl-induced contractions in the guinea pig longitudinal ileal muscle.

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α-NETA | α NETA | αNETA | alpha NETA

GPCR/G Protein

Chemokine Receptor

Chemokine Receptor

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31059-54-8

369.2

C16H20NO ? I

>98% (HPLC)

In Vitro:?DMSO : 31.25 mg/mL (84.63 mM)

C[N+](C)(CCC(C1=CC=C2C=CC=CC2=C1)=O)C.[I-]

N,N,N-trimethyl-γ-oxo-2-naphthalenepropanaminium, monoiodide

(-20℃)

With Ice Pack

≥ 2 years