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Grapiprant
CAS No. 415903-37-6
Grapiprant( CJ-023423 | AAT-007 )
Catalog No. M14424 CAS No. 415903-37-6
A novel EP4 antagonist; an analgesic and anti-inflammatory drug in the piprant class that was approved for Veterinary Medicine for the control of pain and inflammation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 75 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 346 | In Stock |
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| 100MG | 523 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGrapiprant
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NoteResearch use only, not for human use.
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Brief DescriptionA novel EP4 antagonist; an analgesic and anti-inflammatory drug in the piprant class that was approved for Veterinary Medicine for the control of pain and inflammation.
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DescriptionA novel EP4 antagonist; an analgesic and anti-inflammatory drug in the piprant class that was approved for Veterinary Medicine for the control of pain and inflammation associated with osteoarthritis (OA) in dogs.Pain Phase 2 Clinical(In Vivo):Grapiprant (0-50 mg/kg; oral administration; every 24 hours; for 9 months; beagles) is safe for dogs by long-term oral administration. Efficacy of Grapiprant in the treatment of dogs with osteoarthritis needs to be evaluated in other studies.
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In Vitro——
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In VivoGrapiprant (0-50 mg/kg; oral administration; every 24 hours; for 9 months; beagles) is safe for dogs by long-term oral administration. Efficacy of Grapiprant in the treatment of dogs with osteoarthritis needs to be evaluated in other studies . Animal Model:36 beagles of both sexes (9-month-old) Dosage:0 mg/kg, 1 mg/kg, 6 mg/kg, or 50 mg/kg Administration:Oral administration; every 24 hours; for 9 months Result:Long-term oral administration was safe for dogs.
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SynonymsCJ-023423 | AAT-007
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PathwayGPCR/G Protein
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TargetProstaglandin Receptor
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RecptorProstaglandin Receptor
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number415903-37-6
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Formula Weight491.6052
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Molecular FormulaC26H29N5O3S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NCCC1=CC=C(C=C1)N2C(CC)=NC3=C(N=C(C=C32)C)C)NS(C4=CC=C(C=C4)C)(=O)=O
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Chemical NameBenzenesulfonamide, N-[[[2-[4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]amino]carbonyl]-4-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rausch-Derra LC, et al. Am J Vet Res. 2015 Oct;76(10):853-9.
2. Rausch-Derra LC, et al. J Vet Pharmacol Ther. 2016 Dec;39(6):566-571.
3. De Vito V, et al. J Pharm Biomed Anal. 2016 Jan 25;118:251-8.
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