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ONO-1301
CAS No. 176391-41-6
ONO-1301( ONO 1301 | ONO1301 )
Catalog No. M12659 CAS No. 176391-41-6
A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 897 | Get Quote |
|
| 100MG | 1566 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameONO-1301
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NoteResearch use only, not for human use.
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Brief DescriptionA stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase.
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DescriptionA stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase; suppresses the elevation of protein excretion into urine in rats, attenuates the development of bleomycin-induced pulmonary fibrosis and improves survival in bleomycin mice.Thrombosis Discontinued.
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In VitroONO 1301 (ONO-AP 500-02) inhibits collagen-induced aggregation in a concentration-dependent manner, with an IC50 value of 460 nM.ONO-1301 (0-1000 nM) significantly increases alkaline phosphatase (ALP) activity in the primary osteoblasts and ST2 cells.
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In VivoONO-1301 (6 mg/kg; p.o.; /daily for 4 weeks) improves the hemodynamic status of rats with dilated cardiomyopathy after experimental autoimmune myocarditis. Animal Model:Eight-week-old male Lewis rats (rat model of myosin-induced experimental autoimmune myocarditis)Dosage:6 mg/kg Administration:Orally; /daily for 4 weeks Result:Hemodynamic parameters and plasma brain natriuretic peptide (BNP) level were significantly improved.
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SynonymsONO 1301 | ONO1301
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PathwayGPCR/G Protein
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TargetProstaglandin Receptor
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RecptorProstaglandin Receptor
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Research AreaCardiovascular Disease
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IndicationThrombosis
Chemical Information
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CAS Number176391-41-6
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Formula Weight428.488
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Molecular FormulaC26H24N2O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (116.69 mM)
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SMILESO=C(O)COC1=C2CCC(C)=C(CCO/N=C(C3=CC=CC=C3)\C4=CC=CN=C4)C2=CC=C1
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Chemical Name[7,8-dihydro-5-[(E)-[[a-(3-pyridyl)benzylidene]-aminooxy]ethyl]-1 -naphtyloxy]acetic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hayashi K, et al. Jpn J Pharmacol. 1997 Jan;73(1):73-82.
2. Rudd JA, et al. Br J Pharmacol. 2000 Feb;129(4):782-90.
3. Chow KB, et al. Br J Pharmacol. 2001 Dec;134(7):1375-84.
4. Murakami S, et al. Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L59-65.
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