GW-766994( GW766994 )

Catalog No. M14404 CAS No. 408303-43-5

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Product Name

GW-766994
Note

Research use only, not for human use.
Brief Description

GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist.
Description

GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays; reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3, blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures.
In Vitro

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In Vivo

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Synonyms

GW766994
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

Inflammation/Immunology
Indication

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CAS Number

408303-43-5
Formula Weight

451.348
Molecular Formula

C21H24Cl2N4O3
Purity

>98% (HPLC)
Solubility

DMSO : 56 mg/mL 124.07 mM
SMILES

C1COC(CN1CC2=CC(=C(C=C2)Cl)Cl)CNC(=O)NCC3=CC=C(C=C3)C(=O)N
Chemical Name

(S)-4-((3-((4-(3,4-dichlorobenzyl)morpholin-2-yl)methyl)ureido)methyl)benzamide

1. Neighbour H, et al. Clin Exp Allergy. 2014 Apr;44(4):508-16.

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