AZ 13381758( AZ13381758 | CXCR2 SM | AZ-13381758 )

Catalog No. M17040 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AZ 13381758
Note

Research use only, not for human use.
Brief Description

A potent, small molecule CXCR2 inhibitor with IC50 of 26 nM and 30 nM for mCXCR2 and hCXCR2, respectively.
Description

A potent, small molecule CXCR2 inhibitor with IC50 of 26 nM and 30 nM for mCXCR2 and hCXCR2, respectively; inhibits the growth and metastatic potential pancreatic ductal adenocarcinoma, enhances sensitivity to anti-PD1 immunotherapy in vivo; chemical analog of AZD 5069.
In Vitro

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In Vivo

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Synonyms

AZ13381758 | CXCR2 SM | AZ-13381758
Pathway

GPCR/G Protein
Target

Chemokine Receptor
Recptor

Chemokine Receptor
Research Area

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Indication

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CAS Number

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Formula Weight

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Molecular Formula

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Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

5'-chloro-7'-methyl-1'-[[3-(trifluoromethyl)phenyl]methyl]spiro[imidazolidine-5,3'-indole]-2,2',4-trione

1. Steele CW, et al. Cancer Cell. 2016 Jun 13;29(6):832-845.

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