Cart
sales@molnova.com
AJM300
CAS No. 401905-67-7
AJM300( AJM 300 | AJM-300 )
Catalog No. M14377 CAS No. 401905-67-7
AJM300 (AJM 300, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 161 | In Stock |
|
| 5MG | 148 | In Stock |
|
| 10MG | 250 | In Stock |
|
| 25MG | 503 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAJM300
-
NoteResearch use only, not for human use.
-
Brief DescriptionAJM300 (AJM 300, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis.
-
DescriptionAJM300 (AJM 300, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis.Other Indication Phase 3 Clinical.
-
In Vitro——
-
In VivoAnimal Model:Mouse model of colitis induced by adoptive transfer of IL-10 deficient CD4+ T cells Dosage:Diet; 0.03, 0.1, 0.3 or 1% Administration:For 15 days Result:Had a histological improvement in epithelial cell hyperplasia, reduced inflammatory cell infiltration and a decrease in mucus production.Prevented an increase in the colon weight in a model of colitis induced by adoptive transfer of CD4+CD45RB high T cells.
-
SynonymsAJM 300 | AJM-300
-
PathwayCell Cycle/DNA Damage
-
TargetIntegrin
-
RecptorIntegrin
-
Research AreaOther Indications
-
IndicationOther Disease
Chemical Information
-
CAS Number401905-67-7
-
Formula Weight569.439
-
Molecular FormulaC28H26Cl2N4O5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (175.61 mM)
-
SMILESO=C(OC)[C@H](CC1=CC=C(N2C(N(C)C3=C(C=C(N(C)C)C=C3)C2=O)=O)C=C1)NC(C4=C(Cl)C=CC=C4Cl)=O
-
Chemical Namemethyl (S)-2-(2,6-dichlorobenzamido)-3-(4-(6-(dimethylamino)-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)phenyl)propanoate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Halland N, et al. ACS Med Chem Lett. 2014 Jan 10;5(2):193-8.
2. Park SC, et al. World J Gastroenterol. 2018 May 7;24(17):1868-1880.
3. Sugiura T, et al. J Crohns Colitis. 2013 Dec;7(11):e533-42.
4. Yoshimura N, et al. Gastroenterology. 2015 Dec;149(7):1775-1783.e2.
molnova catalog
related products
-
RGDS peptide
RGDS peptide (Arg-Gly-Asp-Ser) is a integrin binding sequence that inhibits integrin receptor function, a tetrapeptide analogue of the cell attachment site of fibronectin.
-
RO0270608
RO0270608, the active metabolite of R411, is an orally active dual α4β1/α4β7 integrin antagonist with anti-inflammatory properties, useful for studying allergic inflammatory responses.
-
GSK-3008348
GSK-3008348 is a novel potent, selective integrin αvβ6 antagonist for the treatment of idiopathic pulmonary fibrosis (IPF).
