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Semapimod
CAS No. 352513-83-8
Semapimod( CNI 1493 | AXD-455 )
Catalog No. M14201 CAS No. 352513-83-8
Semapimod (CNI 1493;AXD-455) is a tetravalent guanylhydrazone that acts as a selective inhibitor of cytokine-inducible arginine transport and NO production, inhibits TLR4 signaling (IC50=0.3 uM) .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSemapimod
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NoteResearch use only, not for human use.
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Brief DescriptionSemapimod (CNI 1493;AXD-455) is a tetravalent guanylhydrazone that acts as a selective inhibitor of cytokine-inducible arginine transport and NO production, inhibits TLR4 signaling (IC50=0.3 uM) .
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DescriptionSemapimod (CNI 1493;AXD-455) is a tetravalent guanylhydrazone that acts as a selective inhibitor of cytokine-inducible arginine transport and NO production, inhibits TLR4 signaling (IC50=0.3 uM) by targeting the TLR chaperone gp96; does not inhibit EDRF activity, inhibits nitric oxide synthesis by inflammatory macrophages; prevents the development of carrageenan-induced footpad inflammation, and conferred protection against lethal LPS challenge in mice.Irritable Bowel Syndrome Phase 2 Clinical.
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In Vitro——
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In VivoAnimal Model:Male OZ rats Dosage:5 mg/kg Administration:I.p; daily for 2 weeks Result:Restored endothelium-dependent vasorelaxation in OZ rats.Animal Model:C57Bl/6 mice (GL261 cells were orthotopically implanted) Dosage:6 mg/kg/day Administration:Intracranially for 1 week, delivered via an osmotic pump Result:Inhibited tumor cell invasion by more than 75%.
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SynonymsCNI 1493 | AXD-455
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR
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Research AreaOther Indications
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IndicationIrritable Bowel Syndrome
Chemical Information
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CAS Number352513-83-8
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Formula Weight744.914
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Molecular FormulaC34H52N18O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(=NN=C(N)N)C1=CC(=CC(=C1)NC(=O)CCCCCCCCC(=O)NC2=CC(=CC(=C2)C(=NN=C(N)N)C)C(=NN=C(N)N)C)C(=NN=C(N)N)C
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Chemical NameN1,N10-bis(3-(1-(2-carbamimidoylhydrazono)ethyl)-5-(1-(2-carbamimidoylhydrazono)ethyl)phenyl)decanediamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bianchi M, et al. Mol Med. 1995 Mar;1(3):254-66.
2. Bianchi M, et al. J Exp Med. 1996 Mar 1;183(3):927-36.
3. Wang J, et al. J Immunol. 2016 Jun 15;196(12):5130-7.
4. Dotan I, et al. Gut. 2010 Jun;59(6):760-6.
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Semapimod hydrochlor...
Semapimod (CNI 1493;AXD-455) is a tetravalent guanylhydrazone that acts as a selective inhibitor of cytokine-inducible arginine transport and NO production.
