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KRIBB11
CAS No. 342639-96-7
KRIBB11( KRIBB-11 | KRIBB 11 )
Catalog No. M14166 CAS No. 342639-96-7
KRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 5MG | 45 | In Stock |
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| 10MG | 67 | In Stock |
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| 25MG | 154 | In Stock |
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| 50MG | 257 | In Stock |
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| 100MG | 499 | In Stock |
|
| 200MG | 702 | In Stock |
|
| 500MG | 1070 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameKRIBB11
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NoteResearch use only, not for human use.
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Brief DescriptionKRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM.
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DescriptionKRIBB11 is a small molecule heat shock factor 1 (HSF1) inhibitor with IC50 of 1.2 uM; inhibits HSF1 downstream target proteins HSP70 and HSP72 synthesis, induces growth arrest and apoptosis in HCT-116 cells, inhibits HSF1-dependent recruitment of p-TEFb to the hsp70 promoter; inhibits tumor growth without body weight loss in mice model.
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In Vitro——
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In Vivo——
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SynonymsKRIBB-11 | KRIBB 11
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSF1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number342639-96-7
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Formula Weight284.27338
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Molecular FormulaC13H12N6O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 27 mg/mL
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SMILESO=[N+](C1=CC=C(NC)N=C1NC2=CC3=C(NN=C3)C=C2)[O-]
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Chemical Name2,6-Pyridinediamine, N2-1H-indazol-5-yl-N6-methyl-3-nitro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yoon YJ, et al. J Biol Chem. 2011 Jan 21;286(3):1737-47.
2. Kang MJ, et al. Biochem Biophys Res Commun. 2017 Oct 21;492(3):304-309.
3. Carpenter RL, et al. Oncotarget. 2017 May 22;8(43):73947-73963.
4. Samarasinghe B, et al. Biochem Pharmacol. 2014 Feb 1;87(3):445-55.
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