Trimebutine maleate

Research use only, not for human use.

Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.

Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects. Target: Opioid Receptor Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.

Cell Proliferation Assay Cell Line:A2780-SP cells Concentration:1 μM, 10 μM, 20 μM Incubation Time:60 h Result:Dose-dependently inhibited A2780-SP cell proliferation.Cell Migration Assay Cell Line:U-87 MG human glioblastoma cells Concentration:10 μM, 50 μM, 100 μM, 200 μM Incubation Time:24 h, 48 h, 72 hResult:Significantly impeded gap closure, with the most effective inhibition observed at 200 μM for all time points after 24, 48, and 72 h of incubation.Apoptosis Analysis Cell Line:A2780-SP cells Concentration:1 μM, 10 μM Incubation Time:24 h Result:Induced G0/G1 arrest and significantly increased the population of AV+/PI+ cells at concentrations over 1 μM.Western Blot Analysis Cell Line:A2780-SP cells Concentration:1 μM, 10 μM Incubation Time:24 h Result:Especially reduced OCT3/4 and SOX2 protein expression related to stemness and ERK phosphorylation related to cell growth, respectively.

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Polibutin | Modulon | Dromostat | EINECS 251-845-9 | Ibutin | Polibutin | TM 906 | Trimebutine maleate, Trimedat

GPCR/G Protein

Calcium Channel

Calcium Channel

Metabolic Disease

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34140-59-5

503.55

C26H33NO9

>98% (HPLC)

DMSO: 38mg/mL

O=C(OCC(C1=CC=CC=C1)(N(C)C)CC)C2=CC(OC)=C(OC)C(OC)=C2.O=C(O)/C=C\C(O)=O

[2-(dimethylamino)-2-phenylbutyl] 3,4,5-trimethoxybenzoate Maleate

(-20℃)

With Ice Pack

≥ 2 years