Cart
sales@molnova.com
Nucleozin
CAS No. 341001-38-5
Nucleozin( Nucleozin )
Catalog No. M14155 CAS No. 341001-38-5
A small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
|
| 5MG | 48 | In Stock |
|
| 10MG | 77 | In Stock |
|
| 25MG | 160 | In Stock |
|
| 50MG | 260 | In Stock |
|
| 100MG | 385 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNucleozin
-
NoteResearch use only, not for human use.
-
Brief DescriptionA small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation.
-
DescriptionA small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation; inhibits infection of MDCK cells by viruses influenza A/WSN/33, H3N2 (clinical isolate) and Vietnam/1194/04 (H5N1) with EC50 of 0.069 uM, 0.16 uM and 0.33 uM in PRA, respectively; protects mice challenged with lethal doses of avian influenza A H5N1; also targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection.Influenza Preclinical.
-
In VitroNucleozin inhibits infection of MDCK cells by the viruses influenza A/WSN/33, H3N2 and Vietnam/1194/04 (H5N1) with an EC50 of 0.069 μM, 0.16 μM and 0.33 μM in plaque reduction assay (PRA) , respectively, severely suppresses viral growth at 0.1 μM and totally inhibites virus production at 1 μM in multicycle growth assays.
-
In VivoNucleozin protectes mice challenged with lethal doses of avian influenza A H5N1.
-
SynonymsNucleozin
-
PathwayMicrobiology/Virology
-
TargetInfluenza Virus
-
RecptorInfluenza Virus
-
Research AreaInfection
-
IndicationInfluenza
Chemical Information
-
CAS Number341001-38-5
-
Formula Weight426.853
-
Molecular FormulaC21H19ClN4O4
-
Purity>98% (HPLC)
-
SolubilityDMSO: 28.66 mg/mL (Need ultrasonic)
-
SMILESO=C(N1CCN(C2=CC=C([N+]([O-])=O)C=C2Cl)CC1)C3=C(C)ON=C3C4=CC=CC=C4
-
Chemical NameMethanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kao RY, et al. Nat Biotechnol. 2010 Jun;28(6):600-5.
2. Amorim MJ, et al. J Virol. 2013 Apr;87(8):4694-703.
3. Su CY, et al. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19151-6.
molnova catalog
related products
-
Dryocrassin ABBA
Dryocrassin ABBA (Dryocrassin) is a flavonoid natural product derived from Dryopteris crassirhizoma, with antiviral and antibacterial activities.
-
34'-Dihydroxyflavone
34'-Dihydroxyflavone (34'-DHF) is an oral active flavonoid with antiviral activity against Influenza A virus.
-
Arbidol hydrochlorid...
Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane.
